Cratus Labs MK677 Ibutamoren
This article breaks down general information on Cratus Labs MK677 Ibutamoren (Click here to buy it now). I have complied info for you guys to check out and help answer any questions you may have! **Like anything you put into your body, please do your OWN research and determine what is right for you**
What Is It?
Looking for a potent GH release that doesn’t involve needles and frustrating timing schedules? Ibutamoren (mk-677) may just fit the bill… People have always been a huge fan of Ipamorelin and CJC1295 (modified GRF 129) when it comes to increasing Growth Hormone levels. But those two peptides require injections, and to really see benefits, you have to inject it multiple times a day, and plan your meals out accordingly (you want to be fairly fasted before using these, and then wait for at least 30 minutes before eating afterwards). So for those of you who don’t want to jack with all that, and want a continuous, 24 hour increase in GH, IGF1 and IGFBP3, then Ibutamoren, an orally active GH secretagogue may be just the ticket. (Via Cratus Labs website)
The benefits of Growth Hormone on metabolism and lean body mass are undeniable. I also go to great lengths pointing out that I don’t think GH is much of a muscle builder per se, and that its ultimate benefit comes down to controlling, or rather offsetting, the detrimental effects of insulin on body composition, when it comes to excessive fat gain. Insulin and IGF1 are amazing at increasing protein synthesis, no doubt, but the real benefits after extended trials of anything that increases GH levels seem to come more in the way of increased leanness, and decreased fat storage. (Via Cratus Labs website)
For many, the use of HGH is not only too costly, but is not a good route to go if overall health and longevity is of utmost importance. HGH, injected exogenously, can create a really awesome environment for body transformation, but with that comes the price of shutting down the HPA production of natural pulses, which interferes with an overall healthier body, for lack of a more scientific term. HGH is great at doing what it does, but leaving it “on” for 8 hours post injection, can lead to insulin resistance and water retention imbalances that ultimately take their toll on the body, especially if someone is using large doses. GH is not supposed to be a 24 hour ON button. It is supposed to peak and drop, along with other hormones, to create the perfect environment for longterm health and antiaging benefits. (Via Cratus Labs Website)
Enter the injectable GH releasers such as Ipamorelin and GRF. These are very, very good at getting the job done when it comes to increasing the body’s own production of Growth Hormone. The biggest problem, though, is that to really take advantage of the benefits, and to fully utilize the peaks, a person would have to inject multiple times a day, and plan out their diet accordingly (too much food in the gut will dampen the release and peak of the GH). But with an orally active version like Ibutamoren, a single dose can increase benefits throughout the entire day, without the need for carrying around needles, watching your diet before and after injections, and all that crap that goes with playing with GH releasers. And the results from the studies that have been seen, show promising results.
Ibutamoren (also known as MK-677), promotes the secretion of the growth hormone (GH) and increases insulin-like growth factor-1. Ibutamoren is technically not a SARM(Selective Androgen Receptor Modulator)
Ibutamoren increases growth hormone levels, by mimicking the action of the hormone ghrelin, and binding to one of the ghrelin receptors (GHSR) in the brain. Activated GHSR stimulates growth hormone release from the brain.
In many instances, these GH releasers would fizzle out after a month, so seeing a consistent benefit over such a long period is a huge thing! Effects of a 7 day treatment with a novel, orally active, growth hormone (GH) secretagogue, MK-677, on 24 hour GH profiles, insulinlike growth factor I, and adrenocortical function in normal young men. To assess the effects of prolonged administration of a novel analog of GH releasing peptide (MK-677), nine healthy young men participated in a randomized, double blind, three-period cross-over comparison of orally administered placebo and 5 and 25 mg doses of MK-677. Each period involved bedtime administration of the drug for 7 consecutive days. At the end of each period, plasma levels of insulinlike growth factor I (IGFI) and IGFbinding protein3 (IGFBP3) were measured at 0745 h, and 24h profiles of plasma GH and cortisol were obtained at 15 min intervals together with the 24h urinary excretion of free cortisol. Profiles of plasma free cortisol were calculated at hourly intervals. The amounts of GH secreted were similar in all three conditions, but GH pulse frequency was increased with both dosages of the drug, primarily because of an increase in the number of low amplitude pulses. Plasma IGFI levels were increased in a dose-dependent manner, whereas IGFBP3 levels were increased only with the highest dosage. There was a positive relationship between GH pulse frequency and IGFI increase. Except for an advance in the nocturnal nadir and in the morning elevation, MK677 had no effect on cortisol profiles. In particular, 24h mean levels of plasma total and free cortisol and urinary excretion of free cortisol were similar under all conditions. The present data suggest that the use of MK-677 for the treatment of relative somatotropic deficiency, particularly in older adults compromised by such deficiency, deserves further investigation.
And a quick note about the cortisol effects… A lot of these peptides increase Cortisol, which is definitely not wanted during the peak of GH release, if physical transformation is a goal. Many of these also increase Prolactin, which can cause a lot of other side effects. So an orally active GH releaser that doesn’t increase Cortisol is definitely going to be a game changer. Two Month Treatment of Obese Subjects with the Oral Growth Hormone (GH) Secretagogue MK677 Increases GH Secretion, Fat-Free Mass, and Energy Expenditure.
We conclude that 2 month treatment with MK-677 in healthy obese males caused a sustained increase in serum levels of GH, IGFI, and IGFbinding protein3. The effects on cortisol secretion were transient. Changes in body composition and energy expenditure were of an anabolic nature, with a sustained increase in fat-free mass and a transient increase in basal metabolic rate. Further studies are needed to evaluate whether a higher dose of MK-677 or a more prolonged treatment period can promote a reduction in body fat. Another quick point. IGFBP3 increases are a good thing. In some instances, we see a binding protein and think of SHBG, Sex Hormone Binding Globulin, which arguably makes Testosterone less effective. In this instance, however, the binding protein IGFBP3 is needed to carry the IGF1 into the cell and activate the receptor. So anything that increases IGF1 AND also increases BP3 is a definite benefit.
The Ghrelin Receptor
No discussion of MK-677 would complete without mention of the ghrelin receptor. Also called the growth hormone secretagogue receptor (GHSR), this receptor is a GPCR that binds ghrelin. In the brain, the ghrelin receptor is located in the the hypothalamic ventromedial nucleus and arcuate nucleus, as well as in ventral tegmental area dopamine neurons projecting to the nucleus accumbens.
- Build Muscle - Since Ibutamoren increases growth hormone and IFG-1, muscle mass/strength & lower body fat are capable.
- Improve Sleep - Ibutamoren can help you reach that deep REM sleep which will allow your body to recovery much more quickly.
- Increase Bone Density - Growth hormone will increase bone turnover and eventually increase the density. This can take quite some time however, studies have shown after a year or longer.
- Possible Nootropic Effects - IFG-1 is know to increase memory (Ibutamoren will increase IFG-1) Also, by increasing the REM sleep duration, your cognitive function may operate at a higher level.
Possible Side Effects
- The most common side effect is increased appetite.
- Slight water retention or bloating
- Skin irritation
Side effects can vary from person to person, but MK677 has known to be very mild.
Typical dosages of Ibutamoren MK677 range from 10-25 mg per day.
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